O-1: Evaluation of Ethnic Patterns of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia/Severe Oligospermia Referred to Royan Institute
نویسندگان
چکیده مقاله:
Background: Microdeletions of the long arm of the chromosome Y are the most common molecular genetic cause of severe infertility in men which affect three regions of AZFa, AZFb and AZFc (Azoospermia factor). These regions contain various genes involved in spermatogenesis. The effect of ethnicity on the patterns of Y chromosome microdeletions has not been extensively studied, particulary in Iranian population. The present study aimed to reveal the ethnic patterns of Y chromosome microdeletions in Iranian infertile men with azoospermia/severe oligospermia referred to Royan institute. Materials and Methods: 1889 infertile men referred to Royan Institute with azoospermia/severe oligospermia were examined for Y chromosome micro-deletions from March 2012 to February 2014. We determined micro-deletions of Y chromosome in AZFa, AZFb and AZFc regions using multiplex PCR and six different STS (Sequence-Tagged Site) markers. The patients were categorized into different ethnic groups based on their birth origin and language of their three male generations. Results: Among 1889 infertile men, we determined 103 cases of Y chromosome micro-deletions (5.4%). Of them, 38 cases were from Azeri origin (36.8%), 28 cases from Fars origin (27.1%), 13 cases from Kurd origin (12.6%), 6 cases from the North of Iran (Gilaki and Mazandarani) (5.8%), 8 cases from Lor origin (7.7%), and 2 cases were from Arab origin (1.9%). There were also 5 cases of non-Iranian (Afghani and Iraqi) origin. We could also determine 130 micro-deletions in AZF regions of 103 Iranian infertile men including 94 microdeletions in AZFc region (72.3%), 29 in AZFb region (22.3%) and 7 in AZFa region (5.3%). This pattern of incidence was nearly similar to the reports from other countries. Conclusion: The pattern of Y chromosome micro-deletions in Iranian infertile male population is similar to the other world regions with AZFc as the most common type, and the ethnic origin of the patients does not affect on this pattern.
منابع مشابه
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia
OBJECTIVE Microdeletions of the Y chromosome long arm are the most common molecular genetic causes of severe infertility in men. They affect three regions including azoospermia factors (AZFa, AZFb and AZFc), which contain various genes involved in spermatogenesis. The aim of the present study was to reveal the patterns of Y chromosome microdeletions in Iranian infertile men referred to Royan In...
متن کاملthe prevalence of y chromosome microdeletions in iranian infertile men with azoospermia and severe oligospermia
objective: microdeletions of the y chromosome long arm are the most common molecular genetic causes of severe infertility in men. they affect three regions including azoospermia factors (azfa, azfb and azfc), which contain various genes involved in spermatogenesis. the aim of the present study was to reveal the patterns of y chromosome microdeletions in iranian infertile men referred to royan i...
متن کاملFrequency of Y Chromosome Microdeletions in Azoospermic and Oligospermic Iranian Infertile Men
Background and Aims: Azoospermia factor (AZF) region of the Y-chromosome has several genes which are responsible for normal spermatogenesis. Microdeletions of these genes are associated with azoospermia and oligospermia. These microdeletions are too small to be detected by karyotyping. They can be easily identified using polymerase chain reaction. The aim of this study is to determine the frequ...
متن کاملprevalence of y chromosome microdeletions in iranian infertile men
this study was designed to determine the frequency of y chromosome azf (azoospermia factor ) subregions, microdeletions in patients with idiopathic nonobstructive azoospermia and severe oligozoospermia. subjects included 40 men who had been referred to infertility clinics for assisted reproduction, 37 were azoospermic and 3 had severe oligospermia. medical history and physical exam revealed no ...
متن کاملThe prevalence of Y chromosome microdeletions in Pakistani infertile men
BACKGROUND Microdeletions of the azoospermia factor locus of the long arm of Y chromosome are an etiological factor of severe oligozoospermia or azoospermia. OBJECTIVE The aim of this study was to investigate the prevalence of Y-chromosome microdeletions in AZF region and their role in infertility in Pakistani population. MATERIALS AND METHODS The type of deletions in AZF locus were detecte...
متن کاملPrevalence of Y chromosome microdeletions in infertile Tunisian men.
Yq microdeletions are the leading genetic cause of male infertility and its detection in clinically relevant for appropriate genetic counseling. The objective of this study was to determine the frequency of Y microdeletion in a group of Tunisian infertile men and to compare the prevalence of these abnormalities with other countries and other Tunisian reported series. Totally, 105 Tunisian idiop...
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عنوان ژورنال
دوره 8 شماره 2.5
صفحات 17- 17
تاریخ انتشار 2014-07-01
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